Abstract

In the past decades, our knowledge about the relationship between cancer and the immune system has increased considerably. Recent years' success of cancer immunotherapy including monoclonal antibodies (mAbs), cancer vaccines, adoptive cancer therapy and the immune checkpoint therapy has revolutionized traditional cancer treatment. However, challenges still exist in this field. Personalized combination therapies via new techniques will be the next promising strategies for the future cancer treatment direction. The increased incidence of cancer worldwide has led to the discovery and development of novel therapeutic agents for the treatment of malignancy. Plant derived bioactive compounds are effective source of anticancer therapy and used as lead compounds for drug development. This review discusses the immune checkpoint blockade therapy on cancer.